I’m Mahitha Kolli, an International Baccalaureate student at CHIREC International School, graduating in 2027. I am drawn to molecular biology and biochemistry because the smallest interactions inside a cell can have profound consequences for human health. From exploring breast cancer biomarkers and cell signalling to working on sustainability and equitable opportunity, I am learning how scientific curiosity can become meaningful action.
I have always been fascinated by the intricate organisation of living systems. Studying biology has made me appreciate how proteins, organelles and signalling pathways coordinate to sustain life—and how small molecular changes can contribute to disease. Cell signalling particularly interests me because it connects molecular events to the behaviour of entire cells and tissues.
Outside science, I value collaboration, communication and service. Competitive volleyball has taught me resilience and responsibility to a team; Model United Nations has challenged me to consider problems from different perspectives; and community projects have shown me that knowledge has greater value when it is shared and applied thoughtfully.
I hope to pursue undergraduate study in molecular biology or biochemistry and continue into research focused on cancer biology, molecular diagnostics and precision medicine. I am particularly interested in the intersection of laboratory experiments and computational analysis: how can we identify meaningful molecular patterns, test their reliability and eventually translate them into better care? I also want to remain involved in environmental and social initiatives. For me, scientific progress is most meaningful when it is rigorous, collaborative and responsive to human needs.
How a focus on biology, chemistry and mathematics grew into a question about the mechanisms of disease.
IB
Current programme
International Baccalaureate Diploma Programme
CHIREC International School
At CHIREC International School, I am pursuing the IB Diploma Programme, with a strong focus on biology, chemistry and mathematics. The programme has encouraged me to connect concepts across disciplines, analyse evidence carefully and balance demanding coursework with independent research, volunteering and sport.
Subject focus
Biology
Chemistry
Mathematics
Balanced alongside
Independent research
Volunteering
Sport
How my interests developed
My interest grew from how cells are built, to how they signal, to what goes wrong in disease — and exploring breast cancer biomarkers made that connection tangible.
01FoundationsCell structure & gene expression
02SignallingHow cells detect signals and regulate responses
03DiseaseQuestions about the mechanisms of disease
04BiomarkersBreast cancer biomarkers
A molecular pattern may inform
Diagnosis
Prognosis
Treatment decisions
Academic outlook
I approach unfamiliar problems by looking for the underlying mechanism, questioning assumptions and testing whether an explanation fits the available evidence. I want university to challenge this way of thinking through rigorous laboratory work, quantitative analysis and conversations with researchers across disciplines.
How I approach a problem
1Look for the underlying mechanism
2Question assumptions
3Test the explanation against the evidence
What I want from university
Rigorous laboratory work
Quantitative analysis
Conversations with researchers across disciplines
04Research
Inquiry at the edges of knowledge
Research exposure across molecular diagnostics, cell signalling, structural biology and vaccine science.
Investigations03
01FeaturedMolecular DiagnosticsOngoingOngoing
Breast Cancer Biomarkers
Research exploration in a Cambridge-linked research setting
Ongoing
One of my most meaningful academic experiences has been exploring the molecular basis of breast cancer biomarkers in a Cambridge-linked research setting. This experience introduced me to the challenge of identifying molecular signals that may help distinguish biological states and support clinical decision-making. It also taught me that the promise of a biomarker depends on careful validation, appropriate interpretation and an understanding of its limitations.
My role
Student researcher — exploring the molecular basis of breast cancer biomarkers
Approach
Review
Setting
Cambridge-linked research setting
Why it matters
The promise of a biomarker depends on careful validation, appropriate interpretation and an understanding of its limitations.
Questions I’m exploring
?How do changes in gene regulation and protein expression reflect tumour biology?
?What makes a biomarker clinically useful rather than merely biologically interesting?
?How can laboratory findings be translated into tests that are reliable across different patient populations?
Through research exposure and tutorials with Professor Taufiq Rahman of the University of Cambridge, I have explored ideas in cell signalling, structural biology and homology modelling. These experiences have deepened my interest in how protein structure influences biological function and how computational models can help scientists frame—and refine—experimental questions.
My role
Tutorial student, mentored by Professor Taufiq Rahman
Approach
Computational
Setting
University of Cambridge (tutorials)
Why it matters
Deepened my interest in how protein structure influences biological function and how computational models can help frame and refine experimental questions.
Key takeaways
Cell signalling — how cells detect signals and regulate their responses
Structural biology — how protein structure influences biological function
Homology modelling — computational models that help frame experimental questions
During work experience at Bharat Biotech in Hyderabad, I had the opportunity to shadow scientists involved in vaccine design. Seeing scientific work in an applied biotechnology setting helped me appreciate the collaboration, testing and discipline required to connect molecular understanding with public-health challenges.
My role
Work-experience student — shadowing scientists involved in vaccine design
Approach
Observational
Setting
Bharat Biotech, Hyderabad
Why it matters
An appreciation of the collaboration, testing and discipline required to connect molecular understanding with public-health challenges.
Key takeaways
Shadowed scientists involved in vaccine design
Observed how applied biotechnology connects molecular science to public health
Saw the collaboration and testing discipline behind industrial research
VaccinesBiotechnologyPublic Health
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05Innovation
Ideas put into action
Projects where curiosity meets inclusion and sustainability — an accessible reading tool concept for Indian-language scripts and student-led environmental action.
Ongoing
ECYCL
Student-led environmental action on electronic waste
2024 – Present
Electronic waste is one of the fastest-growing and least-understood environmental problems, and my involvement in ECYCL has shown me why awareness has to be paired with practical action. Supporting the operations of this student-led organisation, I help coordinate people and projects around e-waste collection drives and educational outreach — organising volunteers, planning logistics and helping communicate why discarded devices need responsible handling. The experience has taught me that sustained environmental progress depends on organisation, teamwork and genuine community participation, not simply good intentions.
Timeline
2024Joined ECYCL and supported early awareness and outreach efforts
2025Took on operational support — coordinating volunteers and logistics for collection drives
2025 – 2026Expanded educational outreach on why and how e-waste should be recycled responsibly
2026 – PresentContinuing to help sustain drives and grow community participation
Concept illustration
Reading should be easy for everyone
English→తెలుగు
Readingshouldbeeasyforeveryone
చదవడంఅందరికీసులభంకావాలి
Reading aloud
Proof-of-concept · specification stage
Indic Dyslexia Support App
Proposed proof-of-concept for accessible reading in Indian-language scripts
2026 – 2027 (Proposed)
I am interested in how technology can make learning more inclusive, and this project explores an accessible reading tool for students who find regional Indian-language scripts difficult to read. The concept is a lightweight mobile prototype: a user enters or scans printed text in a language such as Telugu or Hindi, then listens to it through text-to-speech while the matching words or sentences are highlighted on screen. The proposed design includes adjustable font size and spacing, simplified reading sections and careful handling of complex Indic scripts, where conjunct characters and vowel signs make rendering and word-by-word highlighting harder than in English. It is intended as a proof of concept — not a diagnostic or clinically validated intervention — and the design challenge I care most about is making a digital tool responsive to linguistic diversity without making unsupported claims about dyslexia.
Proposed roadmap
Mid 2026Research and scoping — Indic script rendering, text-to-speech options and accessibility guidelines
Late 2026Design wireframes for reading view, font and spacing controls, and simplified sections
Early 2027Build the prototype — text entry and scanning with highlighted text-to-speech for Telugu and Hindi
Mid 2027Gather informal user feedback and document limitations and next steps
Technologies used
Text-to-Speech
OCR
Unicode Indic Scripts
Mobile Prototype
06Science Blog
From molecules to medicine
Four essays — accessible explanations of synthetic biology, ion channels, diabetes and cancer detection.
I write about scientific ideas that connect molecular mechanisms with medical possibilities. My aim is to make complex biology understandable without overlooking the uncertainties that make research interesting.
01
Synthetic BiologyEssay preview
Synthetic BiologyBuilding Living Machines
What if cells could be programmed to respond to a disease signal?
Synthetic biology brings engineering principles into biology, allowing researchers to design genetic circuits and modify cellular behaviour. Examples such as engineered immune cells and experimental tumour-sensing systems illustrate the field’s promise. They also raise difficult questions about safety, control and responsibility. In this article, I explore how living systems can be engineered—and why biological complexity makes that work so challenging.
Genetic circuits
Engineered immune cells
Tumour-sensing systems
02
Synthetic BiologyEssay preview
Synthetic Biology and DiabetesCells That Respond to Glucose
Could engineered cells one day respond to changing blood-glucose levels by releasing insulin?
Biological feedback loops
Sensing & secretion
Cell signalling
03
Physiology & DiseaseEssay preview
Ion Channels and DiseaseUnderstanding CFTR
A single membrane protein can influence the health of an entire organ.
Chloride & bicarbonate transport
Cystic fibrosis
CFTR modulators
04
OncologyEssay preview
Cancer BiomarkersMolecular Clues for Earlier Detection
Biomarkers can provide important clues about cancer, but interpreting them requires more than finding a measurable molecule.
Protein & genetic markers
Diagnosis & prognosis
Synthetic biomarkers
07Service & Leadership
A life lived with intention
Commitments across policy, community, debate and sport — each shaped by the belief that knowledge has greater value when it is shared and applied thoughtfully.
Commitments04
01ServiceOngoingActive
Volunteer
Global Fair Pay Foundation
Ongoing
Policy & Stakeholder Engagement
My volunteering with the Global Fair Pay Foundation has introduced me to the connection between policy, stakeholder engagement and social equity. Under the mentorship of Dr Saroj Kiran Velamakanni, I support engagement with NGOs and state governments in India to build awareness of the Global Fair Pay Charter and encourage consideration of its adoption from 2027. This experience has helped me appreciate how complex it can be to translate broad principles of fairness into practical initiatives across different institutions and communities.
Mentored by Dr Saroj Kiran Velamakanni
Support engagement with NGOs and state governments in India
Build awareness of the Global Fair Pay Charter and encourage consideration of its adoption from 2027
Work aligned with the wider Sustainable Development Goals
PolicySocial EquityStakeholder EngagementSDGs
02ServiceOngoingActive
Community Volunteer
Good Universe · WWF · Grace Cancer Foundation
Ongoing
Health, Environment & Opportunity
My community experiences have included involvement with Good Universe, WWF and Grace Cancer Foundation. Together, these activities have encouraged me to think about the intersection of health, environmental responsibility and access to opportunity. I want to continue learning how scientific knowledge can be shared in ways that benefit communities beyond research institutions.
Good Universe
WWF
Grace Cancer Foundation
Health, environmental responsibility and access to opportunity
Community ServiceHealthEnvironment
03AthleticsOngoingActive
Volleyball Player
National-level competition
Ongoing
Competitive Volleyball
Volleyball has taught me to remain composed under pressure, communicate clearly and trust the people around me. Competing at national level has also helped me develop the discipline to improve consistently while contributing to a shared goal.
Competed at national level
Composure under pressure and clear communication
Discipline to improve consistently while contributing to a shared goal
AthleticsTeamworkResilience
04Leadership3 conferences
Delegate
Three conferences · Honourable Mention
3 conferences
Model United Nations
Participating in three Model United Nations conferences has helped me become a more confident speaker and a more attentive listener. Preparing for debate has encouraged me to evaluate evidence, understand competing priorities and negotiate constructively. Receiving an Honourable Mention was a rewarding recognition of those efforts.
Participated in three conferences
Received an Honourable Mention
Evaluating evidence, understanding competing priorities and negotiating constructively
DebateDiplomacyPublic Speaking
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08Beyond Academics
Honours earned with dedication
Recognition earned through debate, diplomacy and competitive sport — and moments from the journey beyond the laboratory.
Honours02
01RecognitionSchoolFeatured
Honourable Mention, Model United Nations
Model United Nations conference
A rewarding recognition of efforts across three Model United Nations conferences — evaluating evidence, understanding competing priorities and negotiating constructively.
DebateDiplomacyPublic Speaking
DebateDiplomacyPublic Speaking
02RecognitionNationalFeatured
National-level Competitive Volleyball
Competitive volleyball
Competing at national level has helped me develop the discipline to improve consistently while contributing to a shared goal.
AthleticsTeamworkNational
AthleticsTeamworkNational
Athletics
Competitive Volleyball
Competitive volleyball — composure, communication and trust in the team
Events
Model United Nations
Model United Nations — three conferences and an Honourable Mention
Research
Bharat Biotech Work Experience
Hyderabad
Work experience at Bharat Biotech — shadowing scientists in vaccine design
10Contact
Let’s Connect
For academic enquiries, research collaboration or information about my projects, please get in touch using the form below.